Job Description

Overview Senior Scientific Director, Computational Chemistry Base pay range: $208,200.00/yr - $327,140.00/yr. Location: Boston, MA. Hybrid work arrangement. Responsibilities Co-design molecules for several drug discovery programs across various modalities including small molecules, molecular glues, degraders, and RNA/oligonucleotides Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment Provide crucial technical knowledge and input to project teams to drive decision-making in drug discovery projects by applying in-depth knowledge of SAR, target biology, and predictive methods for assessing on- and off-target activity, physical properties, PK/PD, and synthetic feasibility Implement and execute innovative computational methodologies and tools such as AI-based drug discovery, state-of-the-art commercial and open-source software tools/methods Mentor junior computational chemists on molecular design best practices Open to traveling and spending time on both sites as required Serve as a trusted thought partner, helping to drive ideation and execution of innovative chemistry strategies that meet Takeda’s therapeutic goals Qualifications PhD in Computational Chemistry, Chemical Physics, Medicinal Chemistry, or related disciplines, with 20+ years of experience in pharmaceutical or biotech Deep expertise in structure-based design, ligand-based design, and cheminformatics with a strong background in medicinal chemistry principles Proven track record in using computational methods to drive small molecule drug discovery, from hit identification to clinical candidate selection Extensive knowledge of computational chemistry tools, including docking, molecular dynamics, FEP, QSAR modeling, and generative AI Strong programming and scripting skills (e.g., Python, R, C/C++) with experience in building and automating computational workflows Strong publication record demonstrating innovative contributions to computational chemistry and drug discovery Additional Information The position will be based in Cambridge, MA. This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policy. Compensation & Benefits We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay and transparency with pay practices. Location: Boston, MA U.S. Base Salary Range: $208,200.00 - $327,140.00 The actual base salary offered will depend on factors such as qualifications, experience, skills, education, and location. The salary will align with state or local minimum wage requirements where applicable. U.S. based employees may be eligible for short-term and/or long-term incentives, and benefits including health insurance, a 401(k) plan with company match, disability coverage, life insurance, tuition reimbursement, paid time off, and other well-being benefits. EEO Statement Takeda is committed to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a veteran in accordance with applicable laws. Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time Job Exempt Yes #J-18808-Ljbffr BioSpace

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